Center for Integrative Psychiatry

How Does Spravato Work? Complete Guide

When it comes to innovative treatments for depression, Spravato has been making waves in the mental health community. If you’re curious about how Spravato works and how it compares to ketamine infusion therapy, you’ve come to the right place. In this blog post, we’ll explore the mechanism of action of Spravato and delve into “Complete Guide of How Does Spravato Work?” and the key differences between Spravato and ketamine.

How Does Spravato Work?

Spravato, also known as esketamine, is a prescription medication approved by the FDA for treatment-resistant depression. It belongs to the class of drugs known as NMDA receptor antagonists. Spravato works by targeting and modulating the activity of glutamate, a neurotransmitter in the brain that plays a role in mood regulation.

When administered, Spravato helps restore balance in the brain’s neurotransmitter systems, which can alleviate depressive symptoms. It is typically administered as a nasal spray under the supervision of a healthcare professional.

Is Spravato the Same as Ketamine?

While both Spravato and ketamine are NMDA receptor antagonists, they are not the same. Ketamine is a dissociative anesthetic that has been used off-label to treat depression. Ketamine infusions involve the administration of the drug through an IV drip. In contrast, Spravato is a specifically formulated nasal spray with esketamine as its active ingredient.

Which Is Better Spravato Vs Ketamine Infusion?

When it comes to choosing between Spravato and ketamine infusion for depression treatment, several factors should be considered:

– Administration Method:

Spravato is administered as a nasal spray, while ketamine is typically given through IV infusion.

– FDA Approval:

Spravato has received FDA approval specifically for treatment-resistant depression, while ketamine is used off-label for this purpose.

– Treatment Setting:

Ketamine infusions are often conducted in specialized clinics, whereas Spravato treatment can be administered in a healthcare provider’s office.

– Cost:

The cost of treatment can vary, with Spravato often being more expensive.

Long Story Short

Spravato is an innovative treatment option for individuals with treatment-resistant depression, offering a different approach to depression management than traditional medications. However, the choice between Spravato and ketamine infusion depends on individual circumstances and preferences.


This blog post is for informational purposes only and should not replace the advice of a qualified medical professional. If you’re considering Spravato or ketamine treatment for depression, consult with our mental health specialists to determine the most appropriate option for your needs.

Reach Out To Us

If you’re interested in exploring Spravato vs Ketamine infusion as a depression treatment option, contact the Center for Integrative Psychiatry at 1-877-283-5336 in Coppell, Texas. Our experienced team can provide you with more information and help you make an informed decision regarding your mental health journey. Don’t hesitate to reach out and take the first step toward a brighter future.

Leave a Comment

Your email address will not be published. Required fields are marked *

Call Us:
+1 877-283-5336
Get an Evaluation Appointment Today

Office Locations

Located in Coppell


Working Hours

By Appointment Only

Phone number


Social Media

Book An Appointment
Book An Appointment