Center for Integrative Psychiatry

How Long Do You Stay On Spravato

If you’re considering Spravato (esketamine) for depression treatment, understanding its duration, mechanism of action, certified treatment centers, and patient experiences is crucial. Let’s delve into these aspects to provide you with comprehensive insights, including the key question: How long do you stay on Spravato?

How Does Spravato Work in the Brain 

Spravato, an FDA-approved medication for treatment resistant depression, operates differently from traditional antidepressants. It targets the N-methyl-D-aspartate (NMDA) receptors in the brain, distinct from serotonin and norepinephrine pathways. This unique mechanism offers hope for individuals who haven’t responded to other treatments.

Certified Treatment Centers for Spravato

Finding a reliable treatment center is crucial for safe and effective Spravato therapy. Certified treatment centers ensure adherence to proper protocols, monitoring, and patient support. These centers employ trained professionals who can administer the medication safely and monitor patients for any adverse effects.

Spravato Treatment Reviews

Real patient experiences provide valuable insights into the efficacy and tolerability of Spravato treatment. While individual responses vary, many patients report significant improvements in their depressive disorder symptoms after undergoing Spravato therapy. Reading reviews can help you understand what to expect and make informed decisions about your treatment journey.

Understanding the Duration of Spravato Treatment

The duration of Spravato treatment varies depending on various factors, including the severity of depression, individual response to the medication, and treatment goals. Typically, Spravato is administered in conjunction with an oral antidepressant and psychotherapy. Initially, patients may undergo a few weeks of intensive treatment, including frequent doses of Spravato. As symptoms improve, the frequency of administration may decrease, transitioning to a maintenance phase.

Factors Influencing Treatment Duration

Several factors influence how long do you stay on Spravato:

  1. Response to Treatment: Some patients experience rapid improvement in symptoms, allowing for a shorter treatment duration.
  2. The severity of Depression: Severe or treatment-resistant depression may require longer-term treatment with Spravato.
  3. Underlying Health Conditions: Co-existing medical conditions may impact treatment duration and response.
  4. Individual Treatment Plan: Treatment duration is tailored to each patient’s unique needs and goals.

Adherence to Treatment Plan

To maximize the benefits of Spravato therapy, it’s essential to adhere to the prescribed treatment plan. This includes attending all treatment sessions, following medication instructions, and actively participating in therapy. Open communication with your healthcare provider ensures that any concerns or changes in symptoms are addressed promptly.

Potential Side Effects and Monitoring

While Spravato can be effective, it’s not without potential side effects. Common side effects may include dizziness, dissociation, nausea, and headache. It’s crucial to undergo treatment under the supervision of trained professionals who can monitor for any adverse reactions and adjust the treatment plan as needed.

Additional Information

Is Spravato Covered by Insurance?

Many insurance plans cover Spravato treatment, but coverage may vary depending on your specific plan and provider. It’s essential to check with your insurance company to understand your coverage options and any potential out-of-pocket expenses.

What Should I Expect During a Spravato Treatment Session?

During a Spravato treatment session, you’ll be closely monitored by healthcare professionals. The medication is administered via nasal spray, and you’ll be required to stay at the treatment center for a couple of hours for observation. Some patients may experience mild side effects during or after the session, but these typically subside quickly.

Can Spravato Be Used Alone for Depression Treatment?

Spravato is typically used in conjunction with an oral antidepressant and psychotherapy for the treatment of depression. While it can be effective on its own, combining it with other treatment modalities may enhance its efficacy and long-term benefits.

What Should I Do If I Experience Side Effects From Spravato?

If you experience any concerning side effects from Spravato, such as severe dizziness, confusion, or chest pain, it’s important to seek medical attention immediately. Your healthcare provider can assess the severity of your symptoms and adjust your treatment plan accordingly.

Is Spravato Safe for Long-Term Use?

The long-term safety of Spravato is still being studied, but current research suggests that it can be used safely for an extended period under the supervision of healthcare professionals. Your doctor will monitor your progress and any potential side effects to ensure the continued safety and efficacy of the treatment.


Understanding how long do you stay on Spravato involves considering various factors, including treatment response, severity of depression, and individualized treatment plans. Certified treatment centers offer safe and supportive environments for Spravato therapy, while patient reviews provide valuable insights into real-life experiences. By partnering with your healthcare provider and staying informed, you can navigate your Spravato treatment journey with confidence.

Medical Disclaimer

This article is for informational purposes only and does not constitute medical advice. Consult a qualified healthcare professional for personalized diagnosis and treatment.

Contact Us

For more information about Spravato treatment and depression management, contact the Center For Integrative Psychiatry at 1-877-283-5336.

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