Center for Integrative Psychiatry

Spravato: Safe option for treatment-resistant depression



For individuals struggling with resistant depression, finding relief can be a challenging and disheartening journey. However, there is hope on the horizon with Spravato, an innovative treatment that has shown remarkable results in tackling this persistent condition. In this blog, we will explore the critical aspects of Spravato, its benefits, potential side effects, and its role in transforming the lives of those battling resistant depression.


Let’s first understand Resistant Depression and Spravato Treatment accurately.


Understanding Resistant Depression


Depression is a complex mental health condition that can significantly impact an individual’s emotional and physical well-being. While conventional antidepressants work for many, there are cases where patients experience less to almost no improvement with these medications. This condition is known as resistant depression or treatment-resistant depression (TRD). TRD occurs when a person fails to respond adequately to multiple trials of different antidepressant treatments.


What is Spravato?


Spravato, also known as Esketamine, is an innovative treatment developed by Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson. Approved by the U.S. Food and Drug Administration (FDA) in 2019, Spravato represents a groundbreaking approach to treating resistant depression. Unlike traditional antidepressants targeting serotonin and norepinephrine receptors, Spravato acts on the brain’s glutamate system, a neurotransmitter associated with mood regulation.


Spravato is a nasal spray formulation of esketamine, a chemical mirror image of ketamine, a well-known anesthetic and recreational drug. Ketamine has been used off-label for depression for years, with promising results. Esketamine, as a derivative of ketamine, was developed to provide a more controlled and targeted treatment option. It works by blocking N-methyl-D-aspartate (NMDA) receptors, leading to increased glutamate production, which helps restore neural connections related to mood regulation.


Why consider Spravato Treatment? Perks & Benefits.


Clinical trials have demonstrated the efficacy of Spravato in treating resistant depression. Patients who received Spravato reported a noticeable improvement in their depressive symptoms within hours or days, compared to weeks with traditional antidepressants. This rapid onset of action can be life-changing for those experiencing severe and debilitating depression.


Some of the top benefits of Spravato Treatment are:


  1. Rapid Relief: Spravato has shown rapid onset of action, with some patients experiencing improvement in depressive symptoms within hours or days, compared to the weeks typically required by conventional antidepressants.
  2. Resistant Depression: Spravato is specifically designed for individuals with treatment-resistant depression (TRD), offering hope to those who have not responded adequately to other treatment options.
  3. Potential for Long-lasting Effects: Some patients have reported sustained improvements in their depressive symptoms even after the treatment, indicating the potential for long-term benefits with Spravato.


However, It is crucial to note that the benefits of Spravato can vary from person to person, and individual responses to treatment may differ. As with any medical intervention, it is essential to consult a qualified healthcare professional to determine the most suitable treatment plan for each individual’s unique needs and circumstances. 


CTA: CIP is one of the best options to consult with qualified mental healthcare experts.  


Duration of Spravato Treatment


The treatment typically consists of an initial phase, where Spravato is administered twice a week for several weeks, followed by a maintenance phase, during which the frequency is reduced. Close monitoring and communication with the healthcare provider are essential throughout the treatment process to assess progress and adjust the treatment plan as needed.


Potential Side Effects of Spravato Treatment


While Spravato has shown significant promise, it has potential side effects like any medication. Some common side effects include dissociation, dizziness, nausea, and increased blood pressure. Most of these side effects are mild and temporary, but discussing concerns with the healthcare provider is essential.


Some significant listing side effects reported by patients:


  1. Anxiety or restlessness: Some individuals may experience anxiety or restlessness following Spravato treatment. Discussing any unusual emotions or reactions with the healthcare provider is crucial.
  2. Blurred Vision: Blurred vision has been reported as a potential side effect of Spravato. Patients should avoid tasks that require clear vision until this side effect subsides.
  3. Headache: Headaches can occur as a side effect of Spravato treatment. These headaches are usually mild and temporary, but informing the healthcare provider about any persistent or severe discomfort is essential.




Spravato represents a beacon of hope for individuals suffering from treatment-resistant depression. Its novel mechanism of action and rapid onset of action have the potential to transform the lives of those who have been struggling to find relief. However, it is crucial to approach Spravato treatment with caution and under the guidance of a qualified healthcare professional.


If you’re interested in learning more about Spravato treatment or looking for the best place for this treatment, then please contact the Center for Integrative Psychiatry at 1-877-283-5336. We would be happy to discuss or answer any query you might have.




The information provided in this blog is for educational and informational purposes only and should not be considered medical advice. The content is not a substitute for professional medical diagnosis, treatment, or consultation. Always seek the advice of your physician or qualified mental health provider with any questions you may have regarding a medical condition.

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