Center for Integrative Psychiatry

TMS and Spravato – Finding Depression Treatment Options

In the realm of depression treatment, finding the right approach can be a journey. Two innovative treatments, Transcranial Magnetic Stimulation TMS and Spravato, have emerged as promising options for individuals struggling with depression. Let’s delve into what these therapies entail, how they work, and the nuances of TMS versus Spravato.

What is Transcranial Magnetic Stimulation (TMS)?

Transcranial Magnetic Stimulation, commonly known as TMS, is a non-invasive procedure that utilizes magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. This therapy is typically administered in a clinical setting under the supervision of a trained healthcare professional.

How Does TMS Work for Depression?

TMS therapy involves placing a magnetic coil against the scalp near the forehead. The coil delivers repetitive magnetic pulses, targeting specific areas of the brain associated with mood regulation. Over the course of several sessions, these pulses help modulate brain activity, alleviating depressive symptoms.

What is Spravato Therapy?

Spravato, also known by its generic name esketamine, is an FDA-approved nasal spray medication for treatment-resistant depression. It is a derivative of ketamine, a well-known anaesthetic, but is administered in much lower doses and in a different form.

How Does Spravato Work for Depression?

Spravato acts on the brain’s NMDA receptors, which play a role in mood regulation. By blocking these receptors, Spravato rapidly alleviates depressive symptoms. It is typically administered under the supervision of a healthcare provider in a clinical setting due to safety concerns and the potential for side effects.

TMS and Spravato Together: Exploring Treatments

While both TMS and Spravato offer unique approaches to treating depression, they can also complement each other effectively. TMS focuses on modulating brain activity over time, offering longer-term relief from depressive symptoms. Spravato, on the other hand, provides rapid relief, making it suitable for individuals in acute distress.

TMS vs. Spravato: Understanding the Differences

  • Administration: TMS involves the use of a magnetic coil placed on the scalp, while Spravato is administered as a nasal spray.
  • Treatment Duration: TMS typically requires multiple sessions over several weeks, whereas Spravato may offer rapid relief after just a few doses.
  • Side Effects: While both treatments are generally well-tolerated, side effects such as headache, dizziness, and nausea may occur with TMS, while Spravato may cause dissociation and sedation.

The Role of TMS and Spravato in Depression Treatment

Depression is a complex mental health condition that affects millions of individuals worldwide. Traditional treatments such as medication and therapy may not always provide adequate relief, leading individuals to explore alternative options like TMS and Spravato.

Who Can Benefit from TMS and Spravato?

TMS and Spravato are particularly beneficial for individuals who have not responded to conventional antidepressant medications or therapy. They offer hope for those with treatment-resistant depression, providing new avenues for managing symptoms and improving quality of life.

The Future of Depression Treatment

As research in the field of depression treatment continues to advance, so too do our understanding and options for managing this debilitating condition. TMS and Spravato represent just two examples of the innovative approaches being developed to address the complexities of depression.

Integrating TMS and Spravato into Depression Care

By integrating TMS and Spravato into existing depression care frameworks, healthcare providers can offer a more comprehensive approach to treatment. This may involve combining these therapies with traditional treatments or exploring them as standalone options based on individual patient needs.


In the realm of depression treatment, TMS and Spravato offer promising alternatives for individuals who have not responded to traditional therapies. While they differ in their mechanisms and administration, they share the common goal of providing relief from depressive symptoms. Whether used individually or in combination, these treatments represent a beacon of hope for those navigating the complexities of depression.

Medical Disclaimer

The information provided in this article is for educational purposes only and should not be considered medical advice. Individuals seeking treatment for depression should consult with a qualified healthcare professional to determine the most appropriate course of action based on their individual needs.

Contact Us

If you or a loved one are struggling with depression and would like to explore treatment options, please contact the Center For Integrative Psychiatry at 1-877-283-5336.

By integrating TMS and Spravato into the conversation surrounding depression treatment, individuals can gain access to a wider range of options tailored to their unique needs and preferences. As research continues to evolve in this field, the future holds even greater promise for innovative therapies that offer hope and healing for those affected by depression.

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