Center for Integrative Psychiatry

What to expect during the Spravato treatment process?

Spravato is a nasal spray that contains esketamine, a derivative of ketamine, which is an anesthetic and antidepressant. Spravato is approved by the FDA to treat adults with treatment-resistant depression and major depressive disorder with suicidal thoughts or actions. Spravato is used in combination with an oral antidepressant and under the supervision of a healthcare provider at a certified treatment center.

In this blog post, we will answer some common questions about the spravato treatment process, such as:

  • What to do during spravato treatment
  • – How long is spravato treatment
  • How does spravato work
  • – How long does spravato take to work
  • – How does spravato work in the brain
  • – Spravato reimbursement
  • – Spravato reimbursement guide
  • – Which is better spravato vs ketamine infusion

What to Do During Spravato Treatment

Spravato treatment consists of two phases: an induction phase and a maintenance phase. The induction phase lasts for four weeks, during which you will receive two spravato treatments per week. The maintenance phase starts after the induction phase and lasts for as long as your healthcare provider recommends. The frequency of treatments in the maintenance phase may vary from once a week to once every two weeks.

Before each treatment session, you will need to:

  • Avoid eating for at least two hours and drinking for at least 30 minutes before the session
  • Bring a companion who can drive you home after the session
  • Bring any personal items that can make you comfortable during the session, such as music, headphones, eye mask, blanket, etc.

During each treatment session, you will need to:

  • Administer the spravato nasal spray yourself under the guidance of your healthcare provider
  • Use one device (two sprays) in each nostril for a total of four sprays per session
  • Wait 5 minutes between each spray
  • Sit or lie down in a comfortable and quiet room for at least two hours after the administration
  • Be monitored by your healthcare provider for possible side effects, such as sedation, dissociation, blood pressure changes, etc.
  • Complete a questionnaire about your mood and suicidal thoughts or actions before and after the session

After each treatment session, you will need to:

  • Avoid driving, operating machinery, or doing anything that requires alertness until the next day
  • Follow up with your healthcare provider about your progress and any side effects
  • Continue taking your oral antidepressant as prescribed

How Long Is Spravato Treatment

The duration of spravato treatment process depends on your individual response and your healthcare provider’s recommendation. The induction phase lasts for four weeks, during which you will receive two treatments per week. The maintenance phase starts after the induction phase and lasts for as long as your healthcare provider recommends. The frequency of treatments in the maintenance phase may vary from once a week to once every two weeks.

The length of each treatment session is about two hours, including the administration and observation time. You will need to plan ahead for transportation and recovery time after each session.

How Does Spravato Work

Spravato works by affecting certain brain chemicals called glutamate and GABA, which are involved in mood regulation, stress response, and cognition. Spravato blocks a type of glutamate receptor called NMDA, which reduces the activity of glutamate and increases the activity of GABA. This results in rapid and sustained antidepressant effects.

Spravato also stimulates the growth of new connections between brain cells, which may improve brain function and resilience.

How Long Does Spravato Take to Work

Spravato may start to work within hours or days after the first dose. However, it may take several weeks or months to achieve the full benefits of spravato treatment. Your healthcare provider will monitor your response and adjust your treatment plan accordingly.

Some factors that may affect how long spravato takes to work include:

  • Your diagnosis and severity of depression
  • Your history of antidepressant use and response
  • Your adherence to spravato treatment schedule and oral antidepressant regimen
  • Your lifestyle factors, such as sleep, diet, exercise, stress management, etc.

How Does Spravato Work in the Brain

Spravato works in the brain by affecting certain brain chemicals called glutamate and GABA, which are involved in mood regulation, stress response, and cognition. Spravato blocks a type of glutamate receptor called NMDA, which reduces the activity of glutamate and increases the activity of GABA. This results in rapid and sustained antidepressant effects.

Spravato also stimulates the growth of new connections between brain cells, which may improve brain function and resilience.

Spravato is different from other antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of serotonin and/or norepinephrine in the brain. Spravato has a unique mechanism of action that may be more effective for some people who do not respond to other antidepressants.

Spravato Reimbursement

Spravato is a prescription medication that is covered by most insurance plans, including Medicare and Medicaid. However, the coverage and cost may vary depending on your plan, deductible, copay, coinsurance, etc. You may also need to get prior authorization from your insurance company before starting spravato treatment process.

To help you with spravato reimbursement, you can:

  • Contact your insurance company to verify your benefits and out-of-pocket costs for spravato treatment
  • Ask your healthcare provider or treatment center to submit a prior authorization request to your insurance company on your behalf.
  • Apply for other financial assistance programs, such as patient assistance programs, copay cards, coupons, etc.

Spravato Reimbursement Guide

To help you navigate the spravato reimbursement process, you can download the Spravato Reimbursement Guide, which provides information and resources on:

  • How to find a certified spravato treatment center
  • How to check your insurance coverage and out-of-pocket costs for spravato treatment
  • How to enroll in the Janssen CarePath Savings Program
  • How to access other financial assistance programs
  • How to track your treatment sessions and payments

Which Is Better Spravato vs Ketamine Infusion

Spravato and ketamine infusion are both forms of ketamine-based treatments for depression. However, they have some differences in terms of administration, dosage, side effects, cost, and availability.

Spravato is a nasal spray that contains esketamine, a derivative of ketamine. Spravato is approved by the FDA to treat adults with treatment resistant depression and major depressive disorder with suicidal thoughts or actions. Spravato is used in combination with an oral antidepressant and under the supervision of a healthcare provider at a certified treatment center.

Ketamine infusion is an intravenous injection of ketamine. Ketamine infusion is not approved by the FDA to treat depression, but it is used off-label by some healthcare providers. Ketamine infusion is usually administered in a clinic or hospital setting.

Some of the advantages of spravato over ketamine infusion include:

  • Spravato is FDA-approved and has more evidence of safety and efficacy for depression
  • Spravato is easier and more convenient to administer than ketamine infusion
  • Spravato is more likely to be covered by insurance than ketamine infusion
  • Spravato has fewer side effects than ketamine infusion, such as the lower risk of bladder damage, addiction, or abuse

Some of the advantages of ketamine infusion over spravato include:

  • Ketamine infusion may have faster and stronger antidepressant effects than spravato
  • Ketamine infusion may be more effective for some people who do not respond to spravato
  • Ketamine infusion may be cheaper than spravato if paid out-of-pocket

The choice between spravato and ketamine infusion depends on your individual needs, preferences, and medical history. You should consult with your healthcare provider to determine which option is best for you.

Wrap-Up

Spravato is a nasal spray that contains esketamine, a derivative of ketamine, which is an anesthetic and antidepressant. Spravato is approved by the FDA to treat adults with treatment-resistant depression and major depressive disorder with suicidal thoughts or actions. Spravato is used in combination with an oral antidepressant and under the supervision of a healthcare provider at a certified treatment center.

Spravato treatment process consists of two phases: an induction phase and a maintenance phase. The induction phase lasts for four weeks, during which you will receive two treatments per week. The maintenance phase starts after the induction phase and lasts for as long as your healthcare provider recommends. The frequency of treatments in the maintenance phase may vary from once a week to once every two weeks.

Spravato works by affecting certain brain chemicals called glutamate and GABA, which are involved in mood regulation, stress response, and cognition. Spravato blocks a type of glutamate receptor called NMDA, which reduces the activity of glutamate and increases the activity of GABA.

Medical Disclaimer

This blog post is for informational purposes only and does not constitute medical advice. Sound healing is not a substitute for professional medical care and should not be used to diagnose, treat, cure, or prevent any disease or condition. If you have any health concerns or questions, please consult your doctor before trying sound healing.

Contact Us

If you are interested in learning more about Spravato treatment or other wellness services we offer at the Center For Integrative Psychiatry, please contact us today at 1-877-283-5336. We are a team of dedicated professionals who are passionate about helping you achieve optimal health and well-being. We look forward to hearing from you and supporting you on your wellness journey.

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