The FDA-approved esketamine nasal spray for treatment-resistant depression — given in-office, under supervision, alongside your oral antidepressant.
What is SPRAVATO®?
SPRAVATO® (esketamine) is a prescription nasal spray approved by the FDA for adults with treatment-resistant depression — depression that hasn't responded adequately to prior antidepressants — and for adults with depressive symptoms of major depressive disorder with acute suicidal thoughts or actions. It is used together with an oral antidepressant, not as a replacement for one.
SPRAVATO® works differently from standard antidepressants, which is exactly why it's considered when those haven't brought enough relief. It is not a take-home medication: every dose is self-administered in a certified healthcare setting, under clinical supervision, with a monitoring period afterward.
It's available only through a federal safety program called a REMS (Risk Evaluation and Mitigation Strategy). Because esketamine can cause temporary dissociation, sedation, and blood-pressure increases in the hours after a dose, the FDA requires that it be dispensed and taken only in certified clinical settings — never at home.
Who is a candidate for SPRAVATO®?
SPRAVATO® is considered for adults who meet specific medical criteria — candidacy is decided at an evaluation, not a form:
Treatment-resistant depression
Adults whose depression hasn't responded to adequate trials of more than one antidepressant.
MDD with acute suicidal thoughts
Adults with depressive symptoms of major depressive disorder and acute suicidal thoughts or actions, as part of comprehensive care.
Ready to pair it with medication
SPRAVATO® is used alongside an oral antidepressant, and you can attend supervised in-office sessions with a ride home arranged.
A medical decision, not a form
Screening covers your blood pressure, certain medical conditions, current medications, and full history. We do not treat children or adolescents.
What a supervised SPRAVATO® session looks like
Arrival and check-in
A clinician checks your blood pressure and confirms you're ready for that day's dose.
Plan not to eat for a period beforehand — we'll give you simple prep instructions before your first session.
You self-administer the spray
You self-administer the SPRAVATO® nasal spray under clinical supervision. It takes only moments.
About two hours of monitoring
You rest in a comfortable, quiet space while staff check on you periodically, including repeat blood-pressure checks.
Many patients feel temporary dissociation or sleepiness during this window — that's expected, and it's monitored the whole time.
Heading home with your ride
Once the clinical team clears you, you leave with your ride — no driving until the next day, after a restful night's sleep.
SPRAVATO® in Coppell and across DFW
SPRAVATO® sessions are given in-office at our Coppell clinic — 580 S Denton Tap Rd, Suite 280, Coppell, TX 75019 — where a trained clinical team supervises every dose and the monitoring period that follows.
The consultation to see whether SPRAVATO® is right for you can happen in person or by secure video across Texas. Treatment itself is always in-office, and we see Texas residents only.
Why choose CIP for SPRAVATO®?
Your SPRAVATO® course runs inside full psychiatric care — under physician oversight, coordinated on one chart.
A psychiatry clinic, not a dosing site
Your SPRAVATO® course runs inside full psychiatric care — evaluation, an oral antidepressant plan, and therapy if you want it, all coordinated on one chart.
Physician oversight
Care under Dr. Tahir Khwaja, psychiatrist and Chief Medical Officer, with a clinical team you'll see at every visit.
Both next-step options in one place
We offer SPRAVATO® and TMS, so the recommendation you get is based on fit — not on which single machine a clinic owns.
Honest about candidacy
Candidacy is a medical decision made at an evaluation, not a form you fill out — if SPRAVATO® isn't right for you, we'll say so and lay out the alternatives.
Related services & reading
Common questions about SPRAVATO®
The ketamine question, the at-home rule, driving, side effects, and how fast it works.
